Protein structure-function studies using theoretical and experimental methods.  Current projects:

-KRas oncogenic protein,

-podocin, integral member of the glomerular slit diaphramgm of the kidney,

-dyskerin, catalyzing psudouridylation,

-peptides prone to amyloid aggregation,

-foldamers, sugar-aminoacids,

-acyl-aminoacyl peptidase, the upstream regulator of the proteosome, and

-ACE2, the recptor of coronavirus spike proteins.