Neurodevelopmental disorders of social behaviour and communication are increasingly prevalent and pose a substantial burden to society, being responsible for medical and economic costs estimated around $100 billion in the U.S. in 2020. The alteration of scaffold protein expression and function has been identified as a risk factor for neurodevelopmental disorders (autism spectrum disorders, intellectual disability, attention deficit hyperactivity disorders, etc.). Although many members of the synaptic scaffold proteins have been already described, their exact functions and importance in the generation of neurodevelopmental disorders are not yet fully clarified. Caskin scaffold proteins are novel members of the postsynaptic protein network, which have been showed recently to be indispensable for proper memory formation and synapse development. To date, not much is known about how Caskin1 exerts its postsynaptic functions, thus we aim to understand the deficits that can arise from the lack or abnormal functioning of this novel postsynaptic scaffold protein.