Arpád Dobolyi
Arpád Dobolyi
Professor
Doctor of Science (DSc)
Contact details
Address
1117 Budapest, Pázmány Péter sétány 1/c.
Room
6.409
Phone/Extension
8775
Links
  • 1. Natural sciences
    • 1.6 Biological sciences
      • Behavioural sciences biology
      • Biochemical research methods
  • 3. Medical and Health sciences
    • 3.1 Basic medicine
      • Neurosciences (including psychophysiology)
      • Physiology (including cytology)
neuroscience

Research on brain neuronal networks and molecular processes involved in the regulation of social behaviors. Their pathological changes in neuropsychiatric diseases are also the focus of our interest.

systems biology

Our research is guided by the hypothesis that the brain regulation of behavior can be understood at the molecular level. For this, it is necessary to understand the functioning of the networks that regulate behaviors, and then to analyze the relevant brain areas at the molecular level. As a result of the methodological development of neuroscience, we have network analysis technologies with which we can reveal the brain activity pattern correlating with behavioral elements, and we use genetic methods to selectively manipulate neurons. The neurons that are key to the given behavior are analyzed at the molecular level using RNA sequencing. This gives us the opportunity to intervene with precision when necessary, for example in diseases. The first step is to identify the drug target protein and then influence its function with drugs.

physiology

The team's primary focus is on neuropharmacology. We are on a mission to unravel the complex interactions between drugs and the brain. One of their groundbreaking projects involves studying the neurochemical mechanisms behind brain diseases. The laboratory employs advanced biochemistry techniques to isolate and analyze various compounds. We are particularly interested in understanding the biochemical pathways that lead to neuropsychiatric diseases. By deciphering the intricate biochemical processes at play, we hope to identify potential drug targets for treatment. Additionally, the laboratory is at the forefront of reproductive health research. We are conducting studies to explore the effects of certain pharmaceuticals on reproductive systems. Using animal models and cell cultures, they examine how these drugs impact fertility and reproductive hormone regulation. This research contributes valuable insights into the potential risks and benefits associated with medication use during pregnancy and contraception.